Mark E. Anderson's Lab
Yuejin Wu, Ph.D.
Yuejin Wu earned his Ph.D. in Pharmacology from Tongji Medical University in Wuhan, China in 1990. He has been trained at Peking University (China), University of Montreal (Canada), and Vanderbilt University (U.S.). Yuejin is a founding member of the lab and has contributed extensively to establishing electrophysiological studies, single cell isolation, and other functional experiments in the lab. He is currently focused on studies of the pacemaking mechanism of sinoatrial node cells, especially on the role of intracellular and mitochondrial calcium, as well as calmodulin kinase II regulation in pacemaking activity.
Wu Y, Gao Z, Chen B, Koval OM, Singh MV, Guan X, Hund TJ, Kutschke WJ, Sarma S, Grumbach IM, Wehrens XHT, Mohler PJ, Song LS, Anderson ME. Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A. 2009; 106(14):5972-7. Epub 2009 Mar 10.
Chen B, Wu Y, Mohler PJ, Anderson ME, Song LS. Local control of Ca2+-induced Ca2+ release in mouse sinoatrial node cells. J Mol Cell Cardiol. 2009; 47(5):706-15. Epub 2009 Jul 15.
Hall DD, Wu Y, Domann FE, Spitz DR, Anderson ME. Mitochondrial Calcium Uniporter Activity Is Dispensable for MDA-MB-231 Breast Carcinoma Cell Survival. PLoS One. 2014 May 6; 9(5):e96866. doi: 10.1371/journal.pone.0096866.
Wu Y, Anderson ME. CaMKII in sinoatrial node physiology and dysfunction. Front Pharmacol. 2014 Mar 18; 5:48. eCollection 2014.
Lai MH, Wu Y, Gao Z, Anderson ME, Dalziel JE, Meredith AL. BK channels regulate sinoatrial node firing rate and cardiac pacing in vivo. Am J Physiol Heart Circ Physiol. 2014 Nov 1;307(9):H1327-38. doi: 0.1152/ajpheart.00354.2014. Epub 2014 Aug 29. PubMed PMID: 25172903; PubMed Central PMCID: PMC4217012.
Wu Y, Rasmussen TP, Koval OM, Joiner ML, Hall DD, Chen B, Luczak ED, Wang Q, Rokita AG, Wehrens XH, Song LS, Anderson ME. The mitochondrial uniporter controls fight or flight heart rate increases. Nat Commun. 2015 Jan 20;6:6081. doi: 10.1038/ncomms7081. Erratum in: Nat Commun. 2015;6:7241. PubMed PMID: 25603276; PubMed Central PMCID: PMC4398998.
Rasmussen TP, Wu Y, Joiner ML, Koval OM, Wilson NR, Luczak ED, Wang Q, Chen B, Gao Z, Zhu Z, Wagner BA, Soto J, McCormick ML, Kutschke W, Weiss RM, Yu L, Boudreau RL, Abel ED, Zhan F, Spitz DR, Buettner GR, Song LS, Zingman LV, Anderson ME. Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9129-34. doi: 10.1073/pnas.1504705112. Epub 2015 Jul 7. PubMed PMID: 26153425; PubMed Central PMCID: PMC4517214.
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