Mark E. Anderson's Lab
Qinchuan Wang, Ph.D.
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I trained with Dr. Jim Lin at the University of Iowa and joined the Anderson lab in 2014. My current research interest is focused on how CaMKII mediates both physiological and pathological effects of reactive oxygen species (ROS). CaMKII is activated by ROS through oxidation of a pair of evolutionarily conserved methionine residues in its regulatory domain. I study the physiological role of oxidized CaMKII in exercise, where ROS are abundant and CaMKII activity is important. On the other hand, excessive ROS drive the progression of a number of diseases, including diabetes. CaMKII has been implicated in numerous processes important for glucose homeostasis. I study whether oxidized CaMKII mediates the pathological effects of ROS in diabetic mice generated by high-fat diet feeding.
Scheffer, D.I., Zhang, D.S., Shen, J., Indzhykulian, A., Karavitaki, K.D., Xu, Y.J., Wang, Q., Lin, J.J., Chen, Z.Y., and Corey, D.P. (2015). XIRP2, an Actin-Binding Protein Essential for Inner Ear Hair-Cell Stereocilia. Cell Rep 10, 1811-1818.
Rasmussen, T.P., Wu, Y., Joiner, M.A., Koval, O.M., Wilson, N.R., Luczak, E.D., Wang, Q., Chen, B., Gao, Z., Zhu, Z., et al. (2015). Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart. Proc Natl Acad Sci U S A.
Wang, Q., Lin, J.L., Chan, S.Y., and Lin, J.J. (2013). The Xin repeat-containing protein, mXinbeta, initiates the maturation of the intercalated discs during postnatal heart development. Dev Biol 374, 264-280.
Wang, Q., Lin, J.L., Reinking, B.E., Feng, H.Z., Chan, F.C., Lin, C.I., Jin, J.P., Gustafson-Wagner, E.A., Scholz, T.D., Yang, B., et al. (2010). Essential roles of an intercalated disc protein, mXinbeta, in postnatal heart growth and survival. Circ Res 106, 1468-1478.
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