Recent Publications:


Wu Y, Valdivia HH, Wehrens XH, Anderson ME.  A Single Protein Kinase A or Camodulin Kinase II Site Does Not Control the Cardiac Pacemaker Ca2+ Clock.  Circ Arrhythm Electrophysiol.  2016 Feb;9(2):e003180. PMID: 26857906.


Rasmussen TP, Wu Y, Joiner MA, Koval OM, Wilson NR, Luczak ED, Wang Q, Chen B, Gao Z, Zhu Z, Wagner BA, Soto JE, McCormick ML, Kutschke W, Weiss RM, Yu L, Boudreau RL, Abel ED, Zhan F, Spitz DR, Buettner GR, Song L, Zingman LV, Anderson ME. Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9129-34. PMID: 26153425.


Wu Y, Rasmussen TP, Koval OM, Joiner MA, Hall DD, Chen B, Luczak ED, Wang Q, Rokita AG, Wehrens XHT, Song L, Anderson ME.   The mitochondrial uniporter controls fight or flight heart rate increases.  Nat Commun. 2015 Jan 20;6:6081. PMID: 25603276.


Jaffer OA, Carter AB, Sanders PN, Dibbern ME, Winters CJ, Murthy S, Ryan AJ, Rokita AG, Prasad AM, Zabner J, Kline JN, Grumbach IM, Anderson ME. Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-β-mediated collagen production in a murine asthma model. Am J Respir Cell Mol Biol. 2015 Jan;52(1):106-15. PMID: 24988374


Hall DD, Wu Y, Domann FE, Spitz DR, Anderson ME. Mitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survival. PLoS One. 2014 May 6;9(5):e96866. PMID: 24802861



Selected Publications:


CaMKII is proarrhythmic and CaMKII inhibition is antiarrhythmic


Anderson ME, Braun AP, Schulman H, Premack BA.  Multifunctional Ca2+/calmodulin– dependent protein kinase mediates Ca2+-induced enhancement of the L-type Ca2+ current in rabbit ventricular myocytes.  Circ Res 1994 Nov; 75(5):854-61.  [PMID:7923631]


Anderson ME*, Braun AP, Wu Y, Lu T, Wu Y, Schulman H, Sung RJ.  KN-93, an inhibitor of multifunctional Ca2+/calmodulin dependent protein kinase, decreases early after-depolarizations in rabbit heart.  J Pharmacol Exper Ther 1998 Dec; 287(3):996-1006. [PMID:9864285]


Wu Y, Roden DM, Anderson, ME.  Calmodulin Kinase inhibition prevents development of the arrhythmogenic transient inward current.  Circ Res 1999 Apr 30; 84(8):906-12. [PMID:10222337]


Wu Y, MacMillan LB, McNeill RB, Colbran RJ, Anderson ME.  CaM kinase augments cardiac of L-type Ca2+ current: A cellular mechanism for long QT arrhythmias.  Am J Physiol 1999 Jun; 276(6 Pt 2):H2168-78.  [PMID:10362701]


CaMKII promotes cardiomyopathy and CaMKII inhibition protects against heart failure


Zhang R, Khoo MS, Wu Y, Yang Y, Grueter CE, Ni G, Price EE Jr, Thiel W, Guatimosim S, Song LS, Madu EC, Shah AN, Vishnivetskaya TA, Atkinson JB, Gurevich VV, Salama G, Lederer WJ, Colbran RJ, Anderson ME.  Calmodulin kinase II inhibition protects against structural heart disease.  Nat Med 2005 Apr; 11(4):409-17.  [PMID:15793582]  Commentary in Nat Med, 2005 Apr; 11(4): 379-80 [PMID:15812516]


Khoo MS, Li J, Singh MV, Yang Y, Kannankeril P, Wu Y, Grueter CE, Guan X, Oddis CV, Zhang R, Mendes L, Ni G, Madu EC, Yang J, Bass M, Gomez RJ, Wadzinski BE, Olson EN, Colbran RJ, Anderson ME.  Death, cardiac dysfunction and arrhythmias are increased by calmodulin kinase II in calcineurin-induced cardiomyopathy.  Circulation 2006 Sep 26; 114(13):1352-9. [PMID:16982937]


Singh MV, Kapoun A, Higgins L, Kutschke WJ, Thurman JM, Singh M, Yang J, Guan X, Lowe JS, Weiss RM, Zimmerman K, Yull FE, Blackwell TS, Mohler PJ, Anderson ME.  Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart.  J Clin Invest 2009 Apr; 119(4):986-96.  PMCID: PMC2662543.  Commentary in Nat Med 2009; 15:375.


Joiner ML, Koval OM, Li J, He BJ, Allamargot C, Gao Z, Luczak ED, Hall DD, Fink BD, Chen B, Yang J, Moore SA, Scholz TD, Strack S, Mohler PJ, Sivitz WI, Song LS, and Anderson ME.  CaMKII determines mitochondrial stress responses in heart.  Nature 2012 Nov 8; 491(7423):269-73.  PMCID: PMC3471377. Commentary in Circ Res 2013 Apr 26; 112(9):1208-11 [PMID: 23620234].


Novel mechanisms of cardiac pacemaker physiology and disease


Wu Y, Gao Z, Chen B, Koval OM, Singh MV, Guan X, Hund TJ, Kutschke WJ, Sarma S, Grumbach IM, Wehrens XH, Mohler PJ, Song LS, Anderson M.E.  Calmodulin kinase II is required for fight or flight sinoatrial node physiology.  Proc Natl Acad Sci 2009 Apr 7; 106(14):5972-7. PMCID: PMC2667018.  Chosen as a “From the Cover” article in PNAS Commentary in Sci Signaling 2009; 2:ec130.


Swaminathan PD, Purohit A, Soni S, Voigt N, Singh MV, Glukhov AV, Gao Z, He BJ, Luczak ED, Joiner ML, Kutschke W, Yang J, Donahue JK, Weiss RM, Grumbach IM, Ogawa M, Chen PS, Efimov IR, Dobrev D, Mohler PJ, Hund TJ, Anderson ME .  Oxidized CaMKII causes cardiac sinus node dysfunction in mice.  J Clin Invest 2011 Aug;121(8):3277-88.  PMCID: PMC3223923.  Commentary in J Clin Invest 2011 Aug; 121(8):2975-7. PMCID: PMC3148748.


Gao Z, Rasmussen TP, Li Y , Kutschke W , Koval OM, Wu Y, Wu Y, Hall DD, Joiner ML, Wu XQ, Swaminathan PD, Purohit A , Zimmerman KA, Weiss RM, Philipson K , Song LS, Hund TJ,  Anderson ME.  Genetic inhibition of Na+-Ca2+ exchanger current disables fight or flight sinoatrial node activity without affecting resting heart rate.  Circ Res 2013 Jan 18;112(2):309-17.  PMCID: PMC3562595.  Commentary in Circ Res 2013 Oct 25; 113(10) PMID: 24158576.


Wu Y, Rasmussen TP, Koval OM, Joiner MA, Hall DD, Chen B, Luczak ED, Wang Q, Rokita AG, Wehrens XHT, Song L, Anderson ME.   The mitochondrial uniporter controls fight or flight heart rate increases.  Nat Commun. 2015 Jan 20;6:6081. PMID: 25603276.


Oxidized CaMKII (ox-CaMKII) contributes to cardiovascular, metabolic and pulmonary disease


Erickson JR, Joiner ML, Guan X, Kutschke WJ, Yang J, Oddis CV, Bartlett RK, Lowe JS, O’Donnell SE, Aykin-Burns N, Zimmerman MC, Zimmerman K, Ham AJ, Weiss RM, Spitz DR, Shea MA, Colbran RJ, Mohler PJ, Anderson ME.  A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation.  Cell 2008 May 2; 133(3):462-74.  PMCID: PMC2435269.  Published with accompanying editorial in Cell 2008 May 2; 133(3):397-9.  PMCID: PMC2655315. Commentaries in Nat Med, 2008 May 2; 14(5):612 and Science Signaling, 2008, 1:ec161.


He BJ, Joiner ML, Singh MV, Luczak ED, Swaminathan PD, Koval OM, Kutschke W, Allamargot C, Yang J, Guan X, Zimmerman K, Grumbach IM, Weiss RM, Spitz DR, Sigmund CD, Blankesteijn WM, Heymans S, Mohler PJ, Anderson ME.  Oxidation of CaMKII determines cardiotoxic effects of aldosterone. Nat Med 2011 Nov 13; 17(12): 1610-9. PMCID: PMC3332099.


Luo M, Guan X, Luczak ED, Di L, Kutschke W, Gao Z, Yang J, Glynn P , Sossalla S, Swaminathan PD, Weiss RM, Yang B, Rokita AG,5, Maier LS, Efimov I, Hund TJ, Anderson ME.  Diabetes increases mortality after myocardial infarction by oxidizing CaMKII.  J Clin Invest 2013 Mar 1; 123(3):1262-74. PMCID: PMC3673230. Erratum: J Clin Invest 2013 May 1; 123(5): 2333.


Sanders PN, Koval OM, Jaffer OA, Prasad AM, Businga TR, Scott JA, Hayden PJ,  Luczak ED, Dickey DD,  Allamargot C, Olivier AK, Meyerholz DK, Robison AJ,  Winder DG, Blackwell TS, Dworski R, Sammut D, Wagner BA, Buettner GR, Pope MR, Miller FJ, Dibbern ME, Haitchi HM, Mohler PJ, Howarth PH, Zabner J, Kline JN, Grumbach IM, Anderson ME. CaMKII is Essential for the Proasthmatic Effects of Oxidation.  Sci Trans Med 2013 Jul 24; 5(195):195 ra97. PMID: 23884469.  Commentary in JAMA. 310(9):894.


Purohit A, Rokita AG, Xiaoqun G, Biyi C, Koval OM, Voigt N, Neef S, Sowa T, Gao Z, Luczak ED, Stefansdottir H, Behunin AC, Li N, El-Accaoui RN, Yang B, Swaminathan PD, Weiss RM, Wehrens XH, Song LS, Dobrev D, Maier LS, Anderson ME.  Oxidized CaMKII Triggers Atrial Fibrillation.  Circulation 2013 Oct 15;128(16):1748-57. PMCID: PMC3876034. Commentary in Circulation 2013 Oct 15; 128(16):1724-6. [PMID:24030497].





© Copyright 2015 Mark E. Anderson Lab    |    Neil Wu