Elizabeth (Betsy) Luczak, Ph.D.

 

Instructor and Lab Manager

Biography:

 

Betsy earned her Ph.D. at the Univesity of Colorado Boulder, training with Dr. Leslie Leinwand.  She joined the Anderson lab as a postdoctoral fellow in 2009. Betsy is primarily interested in the molecular mechanisms of the development of heart failure and cardiac arrhythmias.  The lab recently discovered CaMKII as a resident mitochondria protein, and its inhibition in mitochondria is beneficial in several cardiac disease models.  Her current research interests focus on describing a role for CaMKII in mitochondria and metabolism regulation in the heart, and its role in the transition to heart failure.

 

Selected Publications:

 

Rasmussen TP, Wu Y, Joiner ML, Koval OM, Wilson NR, Luczak ED, Wang Q, Chen B, Gao Z, Zhu Z, Wagner BA, Soto J, McCormick ML, Kutschke W, Weiss RM, Yu L, Boudreau RL, Abel ED, Zhan F, Spitz DR, Buettner GR, Song LS, Zingman LV, Anderson ME. Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart. (2015) Proc Natl Acad Sci U S A 21;112(29):9129-34. PMID: 26153425

 

Wu Y, Rasmussen TP, Koval OM, Joiner ML, Hall DD, Chen B, Luczak ED, Wang Q, Rokita AG, Wehrens XH, Song LS, Anderson ME. The mitochondrial uniporter controls fight or flight heart rate increases. (2015) Nature Communications 6:6081.PMID: 25603276

 

Luczak ED, Anderson ME. CaMKII oxidative activation and the pathogenesis of cardiac disease. (2014) Journal of Molecular and Cellular Cardiology 73:112-6. PMID:24530899

 

Luo M, Guan X, Luczak ED, Lang D, Kutschke W, Gao Z, Yang J, Glynn P, Sossalla S, Swaminathan PD, Weiss RM, Yang B, Rokita AG, Maier LS, Efimov IR, Hund TJ, Anderson ME. (2013) Diabetes increases mortality after myocardial infarction by oxidizing CaMKII. Journal of Clinical Investigation 123(3):1262-74. PMID: 23426181

 

Joiner ML, Koval OM, Li J, He BJ, Allamargot C, Gao Z, Luczak ED, Hall DD, Fink BD, Chen B, Yang J, Moore SA, Scholz TD, Strack S, Mohler PJ, Sivitz WI, Song LS, Anderson ME. (2012) CaMKII determines mitochondrial stress responses in heart. Nature 491(7423):269-73. PMID: 23051746

 

Luczak ED, Barthel KKB, Stauffer BL, Konhilas JP, Cheung TH, Leinwand LA. (2011) Remodeling the cardiac transcriptional landscape with diet. Physiological Genomics 43(12):772-80. PMID: 21487031

 

 

 

 

 

 

 

 

 

 

 

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