Mark E. Anderson, M.D., Ph.D.


Professor and Principal Investigator



Mark Anderson is the William Osler Professor of Medicine, the director of the Department of Medicine in the Johns Hopkins University School of Medicine and physician-in-chief of The Johns Hopkins Hospital. A 1981 honors graduate in biology from Macalester College in St. Paul, Minnesota, Dr. Anderson received his Ph.D. in physiology and his M.D. from the University of Minnesota. He then completed his internal medicine residency and fellowships in cardiology and clinical cardiac electrophysiology at Stanford before joining the faculty at Vanderbilt in 1996. In October 2005, he moved to the University of Iowa Carver College of Medicine and in 2009 was named chairman and department executive officer of internal medicine. In 2012, he became director of the Cardiovascular Research Center.  He moved to Johns Hopkins in 2014.


An outstanding scientist, teacher and caregiver, Dr. Anderson has focused his research on the role of the protein CaMKII (Ca2+/calmodulin dependent kinase II) in heart failure and cardiac arrhythmias, a cause of sudden cardiac death. Work from the laboratory has contributed to current concepts about the role of CaMKII in physiology and disease, and is actively engaged in translating fundamental discoveries into improved therapies for patients.  He has published more than 160 peer-reviewed journal articles, book chapters and book reviews, and has been an invited speaker throughout the United States and in more than a dozen nations.  Dr. Anderson is tremendously excited about new and ongoing studies in the laboratory and welcomes interest from potential trainees.


Selected Publications:


Joiner ML, Koval OM, Li J, He BJ, Allamargot C, Gao Z, Luczak ED, Hall DD, Fink BD, Chen B, Yang J, Moore     SA, Scholz TD, Strack S, Mohler PJ, Sivitz WI, Song LS, and Anderson ME.  CaMKII determines mitochondrial stress responses in heart.  Nature 2012 Nov 8; 491(7423):269-73.  PMCID: PMC3471377. Commentary in Circ Res 2013 Apr 26; 112(9):1208-11 [PMID: 23620234]. Selected as a recommended citation by the Faculty of 1000 Biology.


Singh MV, Swaminathan PD, Luczak ED, Kutschke W, Weiss RM, Anderson ME.  MyD88 mediated inflammatory signaling leads to CaMKII oxidation, cardiac hypertrophy and death after myocardial infarction.  J Mol Cell Cardiol 2012 May; 52(5):1135-44. PMCID: PMC3327770.


Gao Z, Rasmussen TP, Li Y , Kutschke W , Koval OM, Wu Y, Wu Y, Hall DD, Joiner ML, Wu XQ, Swaminathan PD, Purohit A , Zimmerman KA, Weiss RM, Philipson K , Song LS, Hund TJ,  Anderson ME.  Genetic inhibition of Na+-Ca2+ exchanger current disables fight or flight sinoatrial node activity without affecting resting heart rate.  Circ Res 2013 Jan 18;112(2):309-17.  PMCID: PMC3562595.


Sanders PN, Koval OM, Jaffer OA, Prasad AM, Businga TR, Scott JA, Hayden PJ,  Luczak ED, Dickey DD,  Allamargot C, Olivier AK, Meyerholz DK, Robison AJ,  Winder DG, Blackwell TS, Dworski R, Sammut D, Wagner BA, Buettner GR, Pope MR, Miller FJ, Dibbern ME, Haitchi HM, Mohler PJ, Howarth PH, Zabner J, Kline JN, Grumbach IM, Anderson ME. CaMKII is Essential for the Proasthmatic Effects of Oxidation.  Sci       Trans Med 2013 Jul 24; 5(195):195 ra97. PMCID: PMC4331168.

Commentary in JAMA. 310(9):894. Selected as a recommended citation by the Faculty of 1000 Biology.


Luo M, Guan X, Luczak ED, Di L, Kutschke W, Gao Z, Yang J, Glynn P , Sossalla S, Swaminathan PD, Weiss RM, Yang B, Rokita AG,5, Maier LS, Efimov I, Hund TJ, Anderson ME.  Diabetes increases mortality after myocardial infarction by oxidizing CaMKII.  J Clin Invest 2013 Mar 1; 123(3):1262-74. PMCID: PMC3673230.  Erratum: J Clin Invest 2013 May 1; 123(5): 2333


Purohit A, Rokita AG, Xiaoqun G, Biyi C, Koval OM, Voigt N, Neef S, Sowa T, Gao Z, Luczak E, Stefansdottir H, Behunin AC, Li N, El-Accaoui RN, Yang B, Swaminathan PD, Weiss RM, Wehrens XH, Song LS,        Dobrev D, Maier LS, Anderson ME.  Oxidized CaMKII Triggers Atrial Fibrillation.  Circulation 2013 Oct 15;128(16):1748-57. PMCID: PMC3876034.         Commentary in Circulation 2013 Oct 15; 128(16):1724-6. [PMID:24030497].  Selected as a recommended citation by the Faculty of 1000 Biology.


Hall DD, Wu Y, Domann FE, Spitz DR, Anderson ME.  Mitochondrial Calcium Uniporter Activity is Dispensable for MDA-MB-231 Breast Carcinoma Cell Survival.  PLoS One 2014 May 6; 9(5):e96866. PMCID: PMC4011874.


Jaffer OA, Carter AB, Sanders PN, Dibbern ME, Winters CJ, Murthy S, Ryan AJ, Rokita AG, Prasad AM, Zabner J, Kline JN, Grumbach IM, Anderson ME. Mitochondiral-targeted antioxidant therapy decreases TGF b Mediated Collagen production in a murine asthma model.”  Am J Respir Cell Mol Biol 2015 Jan;52(2):106-15. PMID: 24988374]


Wu Y, Rasmussen TP, Koval OM, Joiner ML, Hall DD, Chen B, Luczak ED, Wang Q, Rokita AG, Wehrens XH, Song LS, Anderson ME.   The mitochondrial uniporter controls fight or flight heart rate increases.  Nature Communications 2015 Jan 20;6:6081. PMID 25603276.


Rasmussen TP, Wu Y, Joiner MA, Koval OM, Wilson NR, Luczak ED, Want Q, Chen B, Gao Z, Zhu Z, Wagner BA, Soto J, McCormick ML, Kutschke W, Weiss RM, Yu L, Boudreau RL, Abel ED, Zhan F, Spitz DR, Buettner GR, Song S-S, Zingman, LV, Anderson ME.  Inhibition of MCU forces extra mitochondrial adaptations governing physiological and pathological stress responses in heart.  Proceedings of the National Academy of Science (USA), 2015 Jul 21; 112(29):9129-34.   PMCID: PMC4517214.









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