Mark E. Anderson's Lab
Neha Abrol, Ph.D.
Neha accomplished her Ph.D. in the lab of Dr. Seth Robia at Cardiovascular Research Institute, Stritch School of Medicine at Loyola University Chicago. During the course of her Ph.D., she investigated the genetic mutations in cardiac calcium regulatory protein, phospholamban that cause dilated cardiomyopathy and heart failure in humans, focusing specifically on the structural and functional consequences of these mutations on the Calcium ATPase regulatory complex. In the path of preparation for accomplishing her career goals, Neha joined the Anderson lab at Johns Hopkins School of Medicine as a postdoctoral fellow in 2015. Her work in the lab has focused on investigating the role of O-GlcNAcylation of calmodulin kinase II (CaMKII) in diabetic cardiomyopathy and non-diabetic heart failure. Neha is primarily interested in translational applications of her research findings and to answer her novel research questions, she has been using cutting-edge genome engineering tools including CRISPR to design mutant mice models of CaMKII and is also developing transgenic mice models to study O-GlcNAcylation and non-genetic model of type 2 diabetes.
Abrol N, Smolin N, Armanious G, Ceholski DK, Trieber CA, Young HS, Robia SL. Phospholamban C-terminal residues are critical determinants of the structure and function of the calcium ATPase regulatory complex. Journal of Biological Chemistry. 2014 Sep 12;289(37):25855-66.
Abrol N, de Tombe PP, Robia SL. Acute inotropic and lusitropic effects of cardiomyopathic R9C mutation of phospholamban. Journal of Biological Chemistry. 2015 Mar 13;290(11):7130-40.
Soller KJ, Verardi R, Jing M, Abrol N, Yang J, Walsh N, Vostrikov VV, Robia SL, Bowser MT, Veglia G. Rheostatic Regulation of the SERCA/Phospholamban Membrane Protein Complex Using Non-Coding RNA and Single-Stranded DNA oligonucleotides. Nature Scientific Reports. 2015 Aug 21;5:13000.
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